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Sara Tancredi

From their first meeting in the pilot episode, Sara had sensed that Michael was different from the other prisoners. After she checked his academic record, she was surprised that he had graduated with a master's degree. In "Allen", she notices his nervousness as she tests for his glucose count to confirm his diabetes. However, she dismisses it after his test passed.

In Michael's subsequent visits to the infirmary, Sara carefully deflects all his attempts to charm her. When she was required to conduct a medical check-up for Lincoln Burrows (Dominic Purcell), she discovers from Katie that Lincoln is Michael's brother. After a riot broke out in episode "Riots, Drills and the Devil", Sara was temporarily trapped by herself at sick-bay with the prisoners planning to rape her. Michael eventually rescues her using the crawl space up on the ceiling. He claims that he knew his way around because of his previous assignation to clean out the toxic mold for PI (Prison Industry). Sara later finds out that he lied to her which further encourages her to try to figure out what would possess him to rob a bank and end up in prison. She searches for clues about Michael's background, and though she knows that something is utterly suspicious, she can't stop herself from being attracted to him.

Sara becomes jealous though and distances herself from Michael when she discovers he had a conjugal visit from his "wife" in episode "And Then There Were 7". However, she continues to help Michael in subsequent episodes despite their relationship. On Lincoln Burrows' execution day in episode "The Rat", Sara went to her father to ask him to review Lincoln's case after Michael pleaded with her. Her relationship with Michael deepens and they ultimately share a kiss in the infirmary in episode "The Key". However, after she discovers that Michael had stolen the keys from her, Sara distances herself yet again from him. After Michael tells Sara about his planned escape in "Tonight", Sara is confronted with the decision whether she should help Michael or not. Eventually, Sara returns to Fox River at night and unlocks the infirmary door. Horribly distressed at what she had done, Sara injects herself with morphine which she took from the infirmary. Suspected for being an accessory to the escape, the police officers charge into her apartment with an emergency warrant and finds her to be nearly dead from a morphine overdose.

After recovering from her drug overdose in the season two premiere, Sara becomes the target of The Company - the mysterious organization behind Lincoln Burrows' murder setup. Posing as Lance, a homosexual addict at a Narcotics Anonymous meeting, Agent Kellerman (Paul Adelstein) attempts to befriend Sara to find out the whereabouts of Michael Scofield, who left her a message in an origami crane.

However, after her father alerts her of Kellerman's suspicious identity and her father's subsequent death in episode "Buried", Sara becomes part of the show's conspiracy plot as she literally holds the key (left by her father) to information that may exonerate Lincoln. Following this, several attempts on Sara's life is made by The Company, which forces her to find Michael via his coded messages. Her meeting with Michael takes place in episode "Rendezvous" at Gila, New Mexico but their reunion is short-lived when Kellerman and Agent Mahone (William Fichtner) find out about their rendezvous point. At first, Sara is reluctant to leave with Michael to Panama but is captured by Kellerman shortly after. Kellerman proceeds to torture Sara in episode "Bolshoi Booze", in an effort to obtain information about a USB drive he thinks her father gave her. Sara escapes from Kellerman and decides to change her appearance and throws her wallet with her IDs away.

Two episodes later, Sara returns in "The Message", and has travelled from New Mexico to Missouri. She deciphers another coded message from Michael and reunites with him in Evansville, Indiana in episode "Chicago". Together with Michael, Lincoln and Kellerman, Sara travels to Chicago where her father has hidden the audio file of a recorded conversation between Caroline Reynolds and Terrence Steadman that can help prove Lincoln's innocence. On the train to Chicago, Sara admits to Michael that she has fallen in love with him, and they kiss.Later in the episode, Michael admits he has fallen in love with her. Michael and Sara eventually retrieve the audio file with the help of Henry Pope.

After leaving Kellerman by himself, Sara, Michael and Lincoln find out that the audio file is not legally valid to be used as evidence. They decide to use it to blackmail President Caroline Reynolds for a presidential pardon instead. When this fails, Michael and Lincoln are forced to leave the country. After accepting Michael's invitation to leave the country with him in "Panama", Sara realizes she is being tailed and surrenders herself to the FBI in order to let the brothers escape. Sara is then faced with a 12-year prison sentence but just as she is about to plead guilty, Kellerman comes forward to testify on her behalf.

His testimony exonerates Sara and Lincoln in the season finale, and Sara reunites with the brothers in Panama and tells them of the news. However, when Agent Kim suddenly appears and tries to kill Lincoln and capture Michael, Sara shoots Kim in the chest and kills him. Nowhere to run, Michael and Sara surrender themselves to the Panamanian police but to Sara's surprise, Michael confesses to Kim's killing in her stead.

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Sara Tancredi

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